Propanc Biopharma demonstrates the significant effects of proenzyme therapy on the tumor microenvironment
Scientific director concludes observations applicable to all solid tumors
MELBOURNE, Australia, December 21, 2021– (BUSINESS WIRE) – Propanc Biopharma, Inc. (OTCQB: PPCB) (âPropancâ or the âCompanyâ), a biopharmaceutical company developing novel cancer treatments for patients with recurrent and metastatic cancer, has announced today that Ms. Belen Toledo MSc., from the laboratory of Professor Macarena PerÃ¡n Ph.D., University of JaÃ©n, Spain, has recently completed an important experimental thesis on the effects of proenzyme therapy and the impact on the tumor microenvironment, which is key to the development, invasion, metastatic spread and recurrence of solid tumors. Ms Toledo also reconfirmed that proenzymes kill cancer stem cells (SCCs). This research is part of the joint research and drug discovery program “Proenzymes Optimization Project 1” (POP1) of the universities of JaÃ©n and Granada, Spain, designed to produce synthetic recombinant quantities on a commercial scale of the two proenzymes, trypsinogen and chymotrypsinogen.
The encouraging results demonstrate that the proenzymes have a specific effect on tumor cells and CSCs, but also affect other tumor elements in the tumor microenvironment. However, Ms. Toledo’s most significant finding is that the proenzymes also caused a reversal of the malignant tumor phenotype, which was “most unexpected, very exciting and powerfully conclusive.” The process that causes a reversal of the tumor phenotype is called differentiation, which is basically how proenzymes exert anti-tumor, anti-cancer, and anti-metastatic effects. Therefore, proenzyme treatment, also known as differentiation therapy, exerts these effects on malignant cells, but leaves healthy cells alone.
“The tumor microenvironment has some characteristics common to all solid tumors. Proenzymes normalize this tumor microenvironment,” said Dr Julian Kenyon Mb., ChB., MD, Scientific Director of Propanc. “Therefore, the process of cell differentiation induced by the proenzymes will be applicable to all cancers from solid tumors, as well as to sarcomas. This is truly a remarkable discovery and may be the key to unlocking the uncontrolled spread of malignant tumors. , the leading cause of death in cancer patients. Based on these results, I believe there is an urgent need to advance our lead product candidate, PRP, into clinical trials. “
The POP1 program is designed to produce a clinical rescue compound for the Company’s primary product candidate, PRP. The goal is to produce large quantities of commercial trypsinogen and chymotrypsinogen that have minimal batch variation and without sourcing proenzymes from animals. Propanc is undertaking this ambitious research project in collaboration with the universities of JaÃ©n and Granada, led by researchers M. Aitor GonzÃ¡lez MSc. and Mrs. Toledo, supported by Profs. PerÃ¡n and Juan Antonio Marchal, MD, representing the universities respectively, and Dr Kenyon.
About Propanc Biopharma, Inc.
Propanc Biopharma, Inc. (the âCompanyâ) is developing a novel approach to prevent recurrence and metastasis of solid tumors using pancreatic proenzymes that target and eradicate cancer stem cells in patients with cancers of the pancreas, ovary and colorectal. For more information, please visit www.propanc.com.
The company’s new proenzyme therapy is based on the science that enzymes stimulate biological reactions in the body, especially enzymes secreted by the pancreas. These pancreatic enzymes may be the body’s main defense against cancer.
To view the Company’s âMechanism of Actionâ video on its anti-cancer product candidate, PRP, please click on the following link: http://www.propanc.com/news-media/video
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Investor and media relations:
Mr. James Nathanielsz
Propanc Biopharma, Inc.