This hybrid sensor can help with cancer detection, monitoring and treatment response

A “lab-on-a-chip” is a miniature sensor device capable of performing complex biochemical analysis that is considered one of the most promising approaches for the early detection of cancer.

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Moscow: A team of researchers has developed a nanophotonic-microfluidic sensor whose potential applications include cancer detection, monitoring and evaluation of response to treatment.
The study, published in the journal Optics Letters, says the device can identify dissolved gases and liquids at low concentrations with a high degree of accuracy.
A ‘lab on a chip‘ is a miniature sensor capable of performing complex biochemical analysis that is considered to be one of the most promising approaches for the early detection of cancer.

Russian researchers have developed a new nanophotonic-microfluidic hybrid sensor for the highly sensitive analysis of liquids and gases at very low concentrations in solutions.

“Our study is an important step towards creating a compact lab-on-a-chip device capable of not only performing a comprehensive set of blood tests, but also detecting cancer biomarkers at an early stage using a very small amount. of the patient’s blood,” said researcher Gregory Goltsman of HSE Moscow University.

The current device consists of nanophotonic optical sensors on a chip in combination with microfluidic channels above the sensor surface.

Fluids or gases pumped through the channels affect the propagation of optical radiation in highly sensitive nanophotonic devices, changing the spectral characteristics of the output.

By examining these changes, researchers can determine the composition of the sample.

A special feature of the device is the small size of the microfluidic channels that deliver the samples to the sensors.

This allows results to be obtained even from very small samples, which can be critical when on-site analysis is not possible and samples must be transported elsewhere for examination.

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